Welcome to CMRV Lab
Research Interests: From Metal Catalysis to Photocatalysis​
​Our group mainly focuses on the development of novel catalytic methodologies to address challenging problems in synthetic organic chemistry using either transition metal catalysis or visible light photocatalysis ​​​ ​​​​​​​​​​​​​​​​​​​​​​​​​​
C-H ACTIVATION
C-H activation is a potentially crucial technique in the creation of synthetic works. For instance, late-stage functionalization of complex organic molecules offers a way to potentially simplify synthetic approaches and enable the production of a greater range of final products from a single late-stage intermediate. The synthesis of organic molecules was transformed by C–H activation and associated reactions, which also made it possible to use Earth's natural resources more effectively. It addressed numerous difficulties such as harsh environments or low selectivities by the introduction of coordinating and leading groups.
CYCLOHEXADIENONE CHEMISTRY
Cyclohexadienones are appealing synthetic intermediates that have found use in material science and the synthesis of natural products. Because they contain two reactive π-systems, namely alkyne and enone, alkynyl cyclohexadienones have become creative building blocks for obtaining a broad range of heterocycles.
HYDROFUNCTIONALISATION OF UNACTIVATED ALKENES
Intramolecular cyclizations of heteroatom-based nucleophiles with π-systems, catalyzed by transition metals, have shown to be the most effective and adaptable synthetic techniques for obtaining structurally varied heterocyclic derivatives. When the metal-promoted cyclization is followed by a coupling with an external reagent, the strategy's importance in the synthesis of complex molecules becomes even more apparent. One of the primary challenges linked to the functionalization of inactive alkenes is managing the regioselective addition. The directing-group-assisted hydrocarbon functionalization of alkenes has emerged as a promising alternative for functionalizing the unactivated π-systems in response to these problems in recent years.
CARBENE CHEMISTRY
The denitrogenative ring opening of N-sulfonyl-1,2,3-triazoles, catalyzed by Rh(II), has been thoroughly investigated for the synthesis of several heterocycles that are physiologically active. In particular, they have been widely used in a variety of transformations resulting in various nitrogen-containing compounds and heterocycles as a donor/acceptor carbene complex. N-sulfonyl-1,2,3-triazoles are the source of Rh-azavinyl carbene (Rh-AVC), which is widely employed in a variety of chemical transformations and is recognized as a flexible reactive intermediate.
LMCT PHOTOCATALYSIS
The utilization of photoinduced LMCT in a catalytic cycle has gained prominence in recent years. In this process, photoexcited complexes transfers electrons from an electron-rich ligand-centered orbital to a high valent metal-centered orbital. This transition is advantageous because it requires the necessary metal-centered HOMO and ligand-centered LUMO to felicitate the desired transformations. Complexes involving metals such as Fe, Co, Cu, Ce, Bi, etc take part in LMCT photocatalysis.